Uroplakin II + Uroplakin III

Description

Uroplakin II [BC21] and Uroplakin III [BC17] are highly specific antibodies that may be useful in identifying tumors of urothelial origin. With the exception of bladder and ureter, staining was highly specific in various normal and neoplastic tissues in an in-house study. Both antibodies exhibited increased staining sensitivity when compared to Uroplakin III [AU1] in cases of urothelial carcinoma of the bladder. Uroplakin II + Uroplakin III antibody may be a specific and sensitive antibody cocktail for urothelial carcinoma and in discriminating bladder cancer from renal and prostate carcinomas. PATENT PENDING.

SPECIFICATIONS

Specifications

INTENDED USE IVD
FORMAT PrediluteVALENT
SOURCE Mouse Monoclonal
CLONE BC21, BC17Biocare Clone
ISOTYPE IgG1
ANTIGEN Residues 36-50, Uroplakin III
LOCALIZATION Cytoplasmic, Membrane
SPECIES REACTIVITY Human
DATA SHEET & SDS
REFERENCES

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2. Moll R, et al. Uroplakins, specific membrane proteins of urothelial umbrella cells, as
histological markers of metastatic transitional cell carcinomas. Am J Pathol. 1995 Nov;
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3. Kaufmann O, Volmerig J, Dietel M. Uroplakin III is a highly specific and
moderately sensitive immunohistochemical marker for primary and metastatic
urothelial carcinomas. Am J Clin Pathol. 2000 May; 113(5):683-7.
4. Olsburgh J, et al. Uroplakin gene expression in normal human tissues and locally
advanced bladder cancer. J Pathol. 2003 Jan; 199(1):41-9.
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implications in urothelial tumor progression and clinical outcome. Hum Pathol. 2007
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6. Hoang LL, et al. A newly developed Uroplakin II antibody with increased sensitivity
in urothelial carcinoma of the bladder. Arch Pathol Lab Med. 2013; in press.
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