ZytoLight ® SPEC MDM2/CEN 12 Dual Color Probe

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The ZytoLight ® SPEC MDM2/CEN 12 Dual Color Probe is designed for the detection of MDM2 gene amplifications. Well-differentiated liposarcomas (WDLPS), the most common soft tissue tumors in adults, are characterized by the amplification of 12q-derived chromosomal material, harboring the MDM2 oncogene while lipomas show balanced translocations involving 12q13-15. Accordingly, detection of the MDM2 amplification is regarded as a valuable tool for the differential diagnosis between WDLPS and lipomas.


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