Nerve Growth Factor Receptor antibody (NGFR) is a useful immunohistochemical marker, when used in conjunction with the S100 antibody, to aid in the diagnosis of desmoplastic and neurotrophic malignant melanomas, which are often negative for other melanocytic markers (HMB45, MART-1/Melan-A). Studies have shown that NGFR is expressed on Schwann cells, neuronal axons and perineural cells, as well as tumors derived from those cells, to include malignant peripheral nerve sheath tumors, Schwannomas, granular cell tumors and neurofibromas.
DATASHEETS & SDS
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