Ki-67 + Caspase-3 can provide information on cell death vs. cell proliferation in the same tissue section. The Ki-67 nuclear antigen is associated with cell proliferation and is used to grade proliferation rates of tumors. Ki-67 is found throughout the cell cycle that includes the G1, S, G2, and M phases; but not the G0 phase. Apoptosis has gained central importance in the study of many biological processes, including neoplasia, neurodegenerative diseases, and development. Cleaved caspase-3 detects endogenous levels of the large fragment of activated caspase-3, a protease that mediates apoptosis. Caspase-3 does not cross react with other cleaved caspases.
|SOURCE||Mouse Monoclonal, Rabbit Polyclonal|
|ISOTYPE||IgG1 (Ki-67 only)|
|ANTIGEN||Ki-67 and Caspase-3|
|LOCALIZATION||Ki-67: (nuclear): brown Caspase-3: (cytoplasmic / nuclear): red|
|POSITIVE CONTROL||Tonsil or Colon Cancer|
DATASHEETS & SDS
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