Glycophorin A [JC159]


Glycophorin A, which is the major membrane sialoglycoprotein of human red cells and their precursors, is a specific and early marker for the normal erythroid lineage.15 Glycophorin A is expressed at all stages of erythroid differentiation that includes both nucleated and non-nucleated stages of differentiation. Glycophorin A is a very important diagnostic marker of acute erythroid leukemia, being positive in many cases. In approximately 10% of adult acute leukemias the blasts that are classified as lymphoid or undifferentiated myeloid express glycophorin-A on their surface membrane.16,17

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FORMAT ConcentrateONCORE ProPrediluteQ SeriesUltraLine
VOLUME 0.1 ml1.0 ml25 ml6.0 ml60 Tests7 ml
SOURCE Rabbit Monoclonal
SPECIES REACTIVITY Human; others not tested
LOCALIZATION Erythrocyte Membrane

1. Kiernan JA. Histological and Histochemical Methods: Theory and Practice. New York: Pergamon Press 1981
2. Sheehan DC and Hrapchak BB. Theory and Practice of Histotechnology. St. Louis: C.V. Mosby Co. 1980
3. Clinical Laboratory Improvement Amendments of 1988: Final Rule, 57 FR 7163, February 28, 1992.
4. Shi S-R, Cote RJ, Taylor CR. J Histotechnol. 1999 Sep;22(3):177-92.
5. Taylor CR, et al. Biotech Histochem. 1996 Jan;71(5):263-70.
6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.
8. CLSI Quality Standards for Design and Implementation of Immunohistochemistry Assays; Approved Guideline-Second edition (I/LA28-A2) CLSI Wayne, PA USA ( 2011
9. College of American Pathologists (CAP) Certification Program for Immunohistochemistry. Northfield IL. Http:// (800) 323- 4040.
10. O’Leary TJ, Edmonds P, Floyd AD, Mesa-Tejada R, Robinowitz M, Takes PA, Taylor CR. Quality assurance for immunocytochemistry; Proposed guideline. MM4-P. National Committee for Clinical Laboratory Standards (NCCLS). Wayne, PA. 1997;1-46
11. Koretzik K, Lemain ET, Brandt I, and Moller P. Metachromasia of 3- amino-9-ethylcarbazole (AEC) and its prevention in Immunoperoxidase techniques. Histochemistry 1987; 86:471-478.
12. Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983; 14:767
13. Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen: a possible source of error in immunohistochemistry. AmJ Clin Path 1980; 73:626
14. Herman GE and Elfont EA. The taming of immunohistochemistry: the new era of quality control. Biotech & Histochem 1991; 66:194
15. Ekblom M, Borgstr m G, von Willebrand, E, et al. Erythroid blast crisis in chronic myelogenous leukemia. Blood. 1983; 62(3) 591-596.
16. Hughes A, Dhoot GK. Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma. Tumour Biol. 2018 Nov;40(11):1010428318811467.
17. Carulli G, Sammuri P, Domenichini C, et al. Morphologic and immunophenotypic features of a case of acute monoblastic leukemia with unusual positivity for Glycophorin-A. Hematol Rep. 2018;10(4):7823.


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