Description
Cytokeratin LMW (8/18) antibody [5D3] recognizes Cytokeratins (CK) 8 and 18 intermediate filament proteins. In normal tissues, [5D3] recognizes all simple and glandular epithelium. In neoplastic tissues, [5D3] may prove useful to aid in the identification of adenocarcinomas and some squamous cell carcinomas. It is generally negative in keratinizing squamous carcinomas. Studies suggest [5D3] can be used in conjunction with HMW CK to rule out squamous cell carcinoma. Studies have also shown CK 8/18 expression in squamous cell carcinomas of the oral cavity may indicate a decreased survival rate.
SPECIFICATIONS
Specifications
| INTENDED USE | IVD |
|---|---|
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal |
| CLONE | 5D3 |
| ISOTYPE | IgG1 |
| ANTIGEN | CK 8/18 (LMW) |
| LOCALIZATION | Cytoplasmic |
| POSITIVE CONTROL | Skin |
DATASHEETS & SDS
ONCORE PROTOCOL
| ANTIBODY | DOWNLOAD |
|---|---|
| Download Oncore Protocol |
REFERENCES
1. Angus B, et al. J Pathol. 1988 May; 155(1):71-5.
2. Angus B, et al. J Pathol. 1987 Dec; 153(4):377-84.
3. Rattan B, et al. J Clin Diagn Res. 2012 Nov; 6(9):1495-8.
4. Fillies T, et al. BMC Cancer. 2006 Jan; 6:10.
5. Reisenbichler ES, et al. Mod Pathol. 2011 Feb; 24(2):185-93.
6. Wang Y, et al. Diagn Pathol. 2013 Jan 18; 8:8.
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