Description
This rabbit monoclonal antibody recognizes a protein of 36 kDa, identified as Cyclin D1 antibody rabbit (also known as Bcl-1 or PRAD-1). Cyclin D1 antibody rabbit is a regulatory subunit of certain protein kinases thought to advance the G1 phase of the cell cycle. Cyclin D1, when used in tandem with CD5, CD10 and CD23, is a reliable immunohistochemical marker for the mantle cell lymphoma. Studies have shown that Cyclin D1 is a clinical informative marker for invasive breast cancer. Due to the superior technology in the development of this antibody, its binding capacity exceeds mouse monoclonal antibodies and is virtually background free.
SPECIFICATIONS
Specifications
| INTENDED USE | IVD |
|---|---|
| SPECIES REACTIVITY | Human, Mouse, Rat |
| SOURCE | Rabbit Monoclonal |
| CLONE | SP4 |
| ISOTYPE | IgG |
| ANTIGEN | Cyclin D1 |
| LOCALIZATION | Nuclear |
| POSITIVE CONTROL | Mantle cell lymphoma and breast cancer |
DATASHEETS & SDS
REFERENCES
1. Pruneri G, et al. Appl Immunohistochem Mol Morphol. 2005 Dec; 13(4):318-22.
2. Shakir R, Ngo N, Naresh KN. J Clin Pathol. 2008 Aug; 61(8):920-7.
3. Lee A, et al. Jpn J Clin Oncol. 2007 Sep; 37(9):708-14.
4. Mylona E, et al. Histopathology. 2013 Feb; 62(3):472-80.
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