In prostate tissue, mRNA for CK5 and CK14 has been detected in the basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; however, expression of CK5 or CK14 was not identified in invasive prostatic adenocarcinoma. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. In IHC, P504S has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN have been found to express P504S, whereas P504S was nearly undetectable in benign glands.
Formerly known as PIN-4®
|SOURCE||Mouse Monoclonal, Mouse Monoclonal, Mouse Monoclonal, Rabbit Polyclonal|
|ISOTYPE||IgG, IgG1/kappa, IgG2a/kappa, IgG3|
|ANTIGEN||CK14, CK5, P504S, p63|
|LOCALIZATION||Cytoplasmic, Granular cytoplasm, Nuclear|
|STAINING||Brown (DAB), Brown (DAB), Brown (DAB), Red (Warp Red)|
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