The ZytoLight ® SPEC ERBB2/D17S122 Dual Color Probe is designed for the detection of ERBB2 gene amplification frequently observed in solid malignant neoplasms e.g. breast cancer samples. Amplification of the proto-oncogene ERBB2, observed in approximately 20% of all breast cancer samples, has been correlated with a poor prognosis of the disease. Similar results have been obtained for a variety of other malignant neoplasms e.g. ovarian cancer, stomach cancer, and carcinomas of the salivary gland.