ZytoLight ® SPEC ALK Dual Color Break Apart Probe


The ZytoLight ® SPEC ALK Dual Color Break Apart Probe is designed to detect rearrangements involving the ALK gene. ALK translocations are frequently found in anaplastic large cell lymphoma (ALCL), an aggressive non-Hodgkin lymphoma. Additionally, inversions [inv(2)(p21p23)] affecting the ALK gene have been frequently detected in non-small cell lung cancer (NSCLC) and lead to the formation of EML4-ALK fusion transcripts. ALK kinase targeted therapies may represent a very effective therapeutic strategy in NSCLC patients carrying EML4-ALK rearrangements.


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