Terminal Deoxynucleotidyl Transferase

Terminal Deoxynucleotidyl Transferase antibody (TdT) is a nuclear protein widely used as a marker for lymphoblastic leukemia. TdT is a template-independent DNA polymerase which has been shown to be responsible for the addition of nucleotides at the N-region junction of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. Studies have shown that a panel of antibodies consisting of TdT, CD10, CD99 (MIC2), Bcl-2 and CD34 can be used to distinguish lymphoblastic leukemias from small noncleaved cell lymphomas.

Specifications

1. Orazi A, Cotton J, Cattoretti G et al. Terminal deoxynucleotidyl transferase staining
in acute leukemia and normal bone marrow in routinely processed paraffin sections. Am J Clin Pathol 1994 Nov;102(5):640-5
2. Pileri SA et al. Acute leukaemia immunophenotyping in bone-marrow routine sections. . Br J Haematol 1999 May;105(2):394-401.
3. Soslow RA, Bhargava V, Warnke RA. MIC2, TdT, bcl-2, and CD34 expression in paraffin-embedded high-gradelymphoma/acute lymphoblastic leukemia distinguishes between distinct clinicopathologic entities. Hum Pathol 1997 Oct;28(10):1158-65.
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