PTEN antibody, a novel tumor suppressor, functions as a regulator of both cell cycle progression and apoptosis. Potentially, mutation and deletion of PTEN gene may result in a new signal transduction pathway related to human malignant tumors. Studies have demonstrated a reduction of PTEN expression in advanced breast, prostate and other cancers. In addition, studies also suggest that patients with ErbB2 overexpressing tumors and concurrent low levels of PTEN expression have a poor response to trastuzumab treatment.
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