The presence of progesterone receptor (PR) in breast tumors indicates an increased likelihood of response to anti-estrogen (tamoxifen) therapy. The Progesterone Receptor [SP2] antibody clone is a high affinity rabbit monoclonal. A study has shown that the SP2 clone had a much higher affinity as compared to mouse monoclonals for the progesterone receptor. Studies have also shown that the SP2 clone provides supplementary evidence to ER in predicting survival in human breast cancer.
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1. Rossi S, et al. Rabbit monoclonal antibodies: a comparative study between a novel category of immunoreagents and the corresponding mouse monoclonal antibodies. Am J Clin Pathol. 2005 Aug; 124(2):295-302.
2. Cano G, et al. Estimation of hormone receptor status in fine-needle aspirates and paraffin-embedded sections from breast cancer using the novel rabbit monoclonal antibodies SP1 and SP2. Diagn Cytopathol. 2003 Oct; 29(4):207-11.
3. Huang Z, et al. Development of new rabbit monoclonal antibody to progesterone receptor (Clone SP2): no heat pretreatment but effective for paraffin section immunohistochemistry. Appl Immunohistochem Mol Morphol. 2006 June;14(2):229-33.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.