Description
P504S is an enzyme in the ß-oxidation of branched-chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. p63, a homolog of the tumor suppressor p53, encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. Expression of p63 is detected in prostate basal epithelial nuclei in normal prostate; however, is negative in malignant tumors of the prostate gland. p63 + P504S antibody may be an extremely useful aid in diagnosing prostatic intraepithelial neoplasia (PIN), especially in difficult and limited tissues cases.
SPECIFICATIONS
Specifications
| WEIGHT | N/A |
|---|---|
| DIMENSIONS | N/A |
| INTENDED USE | RUO |
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal, Rabbit Polyclonal |
| CLONE | 4A4 N/A |
| ISOTYPE | IgG, IgG2a/kappa |
| ANTIGEN | p63 P504S |
| LOCALIZATION | Nuclear Granular Cytoplasm |
| POSITIVE CONTROL | Normal prostate and prostate adenocarcinoma |
DATASHEETS & SDS
REFERENCES
1. Yang A, et. al. p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities. Mol Cell. 1998;2:305-16.
2. Signoretti S, et. al. p63 Is a Prostate Basal Cell Marker and Is Required for Prostate Development. Am J Pathol. 2000;157:1769-75.
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5. Rubin MA, et. al. α-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer. JAMA. 2002; 287:1662-70.
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7. Zhou M, et. al. Alpha-Methylacyl-CoA Racemase A Novel Tumor Marker Overexpressed in Several Human Cancers and Their Precursor Lesions. Am J Surg Pathol. 2002; 26:926-31.
8. Wu CL, et. al. Analysis of α-Methylacyl-CoA Racemase (P504S) Expression in High-Grade Prostatic Intraepithelial Neoplasia. Hum Pathol. 2004; 35:1008-13.
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10. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.
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