Description
The mouse monoclonal antibody p40 [BC28] recognizes an epitope unique to the p40 protein and may have applications in cases where p63 has traditionally been used. To date, p63 [4A4] has been a frequently used marker of basal epithelium in normal prostate, with expression not typically observed in prostatic adenocarcinoma. A study has shown p40 (M) antibody staining of normal prostate glands and prostatic intraepithelial neoplasia (PIN) equivalent to p63, with no p40 staining observed in prostate cancer. p63 [4A4] recognizes both the p63 and p40 proteins. In contrast to the rabbit polyclonal p40 antibody, p40 [BC28] does not stain macrophages.
SPECIFICATIONS
Specifications
| INTENDED USE | IVD |
|---|---|
| FORMAT | Predilute |
| VOLUME | 3.0 ml |
| SOURCE | Mouse Monoclonal |
| CLONE | BC28, Biocare Clone |
| ISOTYPE | IgG1 |
| ANTIGEN | Amino Acids 5-17 of p40 |
| LOCALIZATION | Nuclear |
| POSITIVE CONTROL | Normal prostate or prostate cancer containing normal glands. |
| SPECIES REACTIVITY | Human |
REFERENCES
1. Signoretti S, et al. p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol. 2000 Dec; 157(6):1769-75. 2. Sailer V, et al. Comparison of p40 and p63 expression in prostate tissues – which one is the superior diagnostic marker for basal cells? Histopathology. 2013 Jul; 63(1):50-6. 3. Bishop JA, et al. p40 is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol. 2012 Mar; 25(3):405-15. 4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.” 5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.
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