MLH-1

MLH-1 [G168-15] recognizes human and mouse MLH-1 (80-85 kDa). MLH-1 antibody and MSH2 are involved in the DNA mismatch repair (MMR) process. Microsatellite instability (MSI) is an alteration of microsatellite repeats during DNA replication and is a hallmark of the inactivation of the MMR genes. These defects in MMR have been related to human carcinogenesis. Immunostaining for MLH-1 and MSH2 may be useful to aid in identifying the most probable gene responsible for the MSI. Studies have shown that the expression level of MLH-1 may be a survival indicator.

Specifications

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

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