Description
The PD7/26/16 and 2B11 antibody clones have been designated as CD45. CD45 belongs to a leukocyte common antigen (LCA antibody) family of glycoproteins with molecular weights of 180, 190, 205 and 220 kDa. CD45 recognizes an antigen found on lymphoid cells. Studies have shown that most neoplastic B-cells and T-cells stain positively with CD45 in leukemia and in non-Hodgkin’s lymphomas; whereas most neoplastic myeloid and erythroid cells are negative. CD45 has also been observed to be unreactive with epithelium and connective tissues in published studies.
SPECIFICATIONS
Specifications
| INTENDED USE | IVD |
|---|---|
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal |
| CLONE | PD7/26/16 and 2B11 |
| ISOTYPE | IgG1/kappa |
| ANTIGEN | CD45 (Leukocyte Common Antigen) |
| LOCALIZATION | Cell surface |
| POSITIVE CONTROL | Tonsil or lymphoma |
DATASHEETS & SDS
INTERNATIONAL
REFERENCES
1. Muzaffar S, et al. Immunophenotypic analysis of non-Hodgkin’s lymphoma. JPMA J Pak Med Assoc. 1997 Apr; 47(4):106-9.
2. Michels S, et al. Immunostaining for leukocyte common antigen using an Amplified avidin-biotin-peroxidase complex method and paraffin sections. A study of 735 hematopoietic and nonhematopoietic human neoplasms. Arch Pathol Lab Med. 1987 Nov; 111(11):1035-39.
3. Kurtin PJ, Pinkus GS. Leukocyte common antigen-a diagnostic discriminant between hematopoietic and nonhematopoietic neoplasms in paraffin sections using monoclonal antibodies: correlation with immunologic studies and ultrastructural localization. Hum Pathol. 1985 Apr; 16(4):353-65.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.
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