H3K27me3 [C36B11]


H3K27me3 (histone 3 lysine 27 trimethylation) is an epigenetic mark that plays a critical role in regulation of gene expression. The dysregulation of H3K27me3 is implicated in the genesis and progression of cancer. Studies indicate that H3K27me3 plays a role in the creation and maintenance of cell type-specific programs of transcriptional control for a wide variety of species and cell fates.1 H3K27me3 expression was shown to be a significant prognostic indicator in breast, ovarian and pancreatic cancers. Low expression of H3K27me3 correlated with significantly shorter overall survival time compared to individuals with high H3K27me3 expression.2 H3K27me3 may be a useful marker in diagnosing malignant peripheral nerve sheath tumors (MPNSTs) and providing molecular insight in progression of prostate cancer.3,4



FORMAT ConcentrateONCORE ProPrediluteQ SeriesUltraLine
VOLUME 0.1 ml1.0 ml6.0 ml60 Tests7 ml
SPECIES REACTIVITY Human; others not tested
SOURCE Rabbit Monoclonal

1. Arthur RK, et al. Evolution of H3K27me3-marked chromatin is linked to gene expression evolution and to patterns of gene duplication and diversification. Genome Res. 2014 July; 24:1115-24.
2. Wei Y, et al. Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Mol Carcinog. 2008 Sep; 47(9):701-06.
3. Prieto-Granada CN, et al. Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation induced MPNST. Am J Surg Pathol. 2016 Apr; 40(4):479-89.
4. Ngollo M, et al. Global Analysis of H3K27me3 as an Epigenetic Marker in Prostate Cancer Progression. BMC Cancer. 2017; 17:261.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.


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