Gross Cystic Disease Fluid Protein-15

Glycoproteins, including Gross Cystic Disease Fluid Protein-15 antibody (GCDFP-15), are considered to be markers of apocrine differentiation. Numerous studies have shown GCDFP-15 to be a specific marker for breast cancer in formalin-fixed, paraffin-embedded tissues and in cytologic preparation (fine needle aspirates). Studies on breast cancer have shown that GCDFP-15 associated significantly with a profile of good prognosis tumors. Another breast cancer study showed that 73.3% of invasive breast carcinomas expressed GCDFP-15. Other types of tissues that express GCDFP-15 are axillary sweat glands and submandibular salivary glands.

Specifications

1. Hall RE, Clements JA, Birrell SN, Tilley WD. Prostate-specific antigen and gross cystic disease fluid protein-15 are co-expressed in androgen receptor-positive breast tumours. Br J Cancer 1998 Aug;78(3):360-5.
2. Viacava P, Naccarato AG, Bevilacqua G. Spectrum of GCDFP-15 expression in human fetal and adult normal tissues. Virchows Arch 1998 Mar;432(3):255-60.
3. Fiel MI, Cernaianu G, Burstein DE, Batheja N. Value of GCDFP-15 (BRST-2) as a specific immunocytochemical marker for breast carcinoma in cytologic specimens. Acta Cytol 1996 Jul-Aug;40(4):637-41.
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