The estrogen receptor antibody (ER) is a 66 kDa protein that acts as an estrogen-dependent, nuclear hormone receptor. Studies have shown ER is present in the nuclei of epithelial cells in normal breast and endometrial tissues, as well as a subset of breast carcinomas. The ER protein has six functionally discrete domains; labeled A through F. ER [1D5] reacts with the amino-terminal domain in the A/B region of ER-alpha. This clone has been established to work in formalin-fixed, paraffin-embedded tissues and has been published in numerous breast cancer research studies.
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1. Paech K, et al. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 97. Sept 5; 277(5331):1508-1510.
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