Description
Clusterin antibody, also known as Apo lipoprotein J, has been implicated in numerous processes including active cell death. Clusterin is expressed in normal brain and has been reported to be overexpressed in anaplastic large cell lymphoma (ALCL) and in pancreatic, breast, prostate and ovarian cancers. Clusterin has been shown to stain 95% of systemic ALCL, including 100% of ALK-1(+) and 91% of ALK-1(-) ALCL. Studies have shown that clusterin may be a useful diagnostic marker for ALCL, especially in ALK-1(-) cases. Overexpression of clusterin appears to be a useful prognostic factor for patients with ovarian carcinomas.
SPECIFICATIONS
Specifications
| WEIGHT | N/A |
|---|---|
| DIMENSIONS | N/A |
| INTENDED USE | IVD |
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal |
| CLONE | 41D |
| ISOTYPE | IgG1/kappa |
| ANTIGEN | Clusterin alpha chain |
| LOCALIZATION | Cytoplasmic or paranuclear |
| POSITIVE CONTROL | Brain or anaplastic large cell lymphoma |
DATASHEETS & SDS
REFERENCES
1. Fu Y, et al. Mol Med Rep. 2013 Jun; 7(6):1726-32.
2. Partheen K, et al. Int J Cancer. 2008 Nov; 123(9):2130-7.
3. Lae ME, Ahmed I, Macon WR. Am J Clin Pathol. 2002 Nov; 118(5):773-9.
4. Shannan B, et al. Cell Death Differ. 2006 Jan; 13(1):12-9.
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