CD45RO antibody recognizes an 180 kDa protein, identified as isoform of leukocyte common antigen (CD45RO). Studies have shown the CD45RO antibody reacts with mature activated T-cells, most thymocytes and a sub-population of resting T-cells within both CD4 and CD8 subsets. Reportedly, the UCHL-1 clone of the CD45RO antibody is useful for the identification of normal T-cells and T-cell lymphomas. Other studies have demonstrated that UCHL-1 shows no reactivity with normal B-cells or natural killer cells, but reacts with granulocytes and monocytes.
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