CD247 is a 16-kDa T-cell surface glycoprotein, also known as CD3 zeta-chain or T-cell antigen receptor (TCR)-Z, which constitutes part of the TCR complex. CD247 is a crucial molecule in the structure, expression, and function of TCR and natural killer (NK) cell-activating receptors. When CD247 is downregulated, T-cell responsiveness and proliferative capacity will be altered (1).
CD247 staining was observed in various proportions of tumor cells and tumor-infiltrating lymphocytes (TILs), localized in the cytoplasm. Reduced levels of CD247 in both TILs and peripheral blood lymphocytes are associated with many cancers including gastric carcinoma, head and neck cancer, B-cell lymphoma, and renal carcinoma. CD247 plays an important role in signal transduction and may be used as a biomarker for evaluating the status of the immune system (2,3). Studies suggest that CD247 may be a therapeutic target for ovarian cancer treatment (1).
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1. Ye W, Zhou Y, Xu B, et al. CD247 expression is associated with differentiation and classification in ovarian cancer. Medicine (Baltimore).
2. Tartour E, Latour S, Mathiot C, et al. Variable expression of CD3‐ ζ chain
in tumor‐ infiltrating lymphocytes (TIL) derived from renal‐ cell carcinoma:
Relationship with TIL phenotype and function.
Int. J. Cancer.1995; 63: 205-212.
3. Wang Q, Li P, Wu W. A systematic analysis of immune genes and overall
survival in cancer patients. BMC Cancer. 2019;19(1):1225.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-
22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains
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5. Clinical and Laboratory Standards Institute (CLSI). Protection of
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Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.