Description
CD23 antibody is a 45-kDa glycoprotein that acts as a receptor for IgE. It is expressed by interleukin-4 activated B-lymphocytes, by activated macrophages, and by a proportion of follicular dendritic cells. CD23 overexpression has been observed on well-developed follicular dendritic cells in the germinal centers of lymph nodes from patients with Kimura’s disease. CD23, along with CD21, CD35 and vimentin, may be used to identify follicular dendritic cells. CD23 has been shown to aid in the differentiation of small lymphocytic lymphomas and mantle cell lymphoma.
SPECIFICATIONS
Specifications
| WEIGHT | N/A |
|---|---|
| DIMENSIONS | N/A |
| INTENDED USE | IVD |
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal |
| CLONE | 1B12 |
| ISOTYPE | IgG1 |
| ANTIGEN | CD23 |
| LOCALIZATION | Cytoplasmic and cell membrane |
| POSITIVE CONTROL |
DATASHEETS & SDS
| Download Data Sheet |
| Download RUO Data Sheet for International |
| Download SDS Sheet |
Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.
REFERENCES
1. Jin MK, et al. Histopathology. 2011 Mar; 58(4):586-92.
2. Akatsuka N, et al. Auris Nasus Larynx. 2011 Jun; 38(3):362-6.
3. Malik A, et al. J Cancer Res Ther. 2012 Apr-Jun; 8(2):306-7.
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